Malignant fibrous histiocytoma of the breast
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Mammograms show a round, dense mass with fine spiculated margins.
Wide local excision with tumour-free margins and a sentinel node biopsy was performed.
The final histology showed a high-grade spindle cell tumour, with marked nuclear atypia and 10 mitotic figures per 10 hpf. The value of Ki-67 labelling index was 35 %.
The sentinel node was negative for metastases.
The neoplastic cells were negative for desmin, CD34, CKAE1/AE3, CK34bE12, calponin and positive for AML and vimentin.
Primary malignant fibrous histiocytoma (MFH) of the female breast occurs very rarely, less than 1% of all breast malignancies
At 5-year follow-up, the patient is alive and well without evidence of disease.
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