Malignant melanoma metastasis to the thymus

Case contributed by Dr Henry Knipe


Follow-up from clinic.

Patient Data

Age: 75 years
Gender: Male
Solid 2.3 cm anterior mediastinal mass. No enlarged lymph nodes.
Nuclear medicine


Anterior mediastinal mass demonstrated avidity. 

The patient proceeded to resection of the anterior mediastinal mass. 


MACROSCOPIC DESCRIPTION: "Thymus": A piece of soft yellow fatty tissue 22g, 52x50x22mm containing a friable tan and brown nodule 23x15x13mm. 

MICROSCOPIC DESCRIPTION: Sections of thymus and adipose tissue show a nodule of tumour comprising sheets of discohesive cells with eosinophilic cytoplasm, pleomorphic nuclei, clumped chromatin and large nucleoli. Scattered tumour cells have brown intracytoplasmic pigment. Tumour extends to the inked margin. The remaining thymus is unremarkable. By immunohistochemistry the tumour cells are positive for Sox10, HMB45 and Melan A.


Thymus: Metastatic malignant melanoma.

Case Discussion

Metastases to the thymus are very rare with imaging features non-specific. They are usually not included in the differential for an anterior mediastinal mass. This patient did have a history of malignant melanoma

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Case information

rID: 51402
Published: 14th Feb 2017
Last edited: 14th Aug 2019
System: Chest, Oncology
Inclusion in quiz mode: Included

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