Marchiafava Bignami syndrome (probable)
No past medical or psychiatric history. Presented to psychiatry unit 10 months ago due to apathy, withdrawn, loss of appetite and loss of weight; which has occurred within several months. He was diagnosed with Major Depressive Disorder and treated as such. He represented 6 months ago with severe loss of weight and withdrawn, his speech output has reduced to minimal and currently can't hold conversation at all. He also appeared very cachectic. Also noted one possible episode of auditory hallucination. Noted this afternoon had stiffness of unilateral lower limb. No fever.
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This case illustrates what are probably features of prior Marchiafava Bignami syndrome. Subsequent history obtained of the patient, confirmed the presence of a period of severe binge drinking while depressed.
Prior to this, there was no history of alcohol abuse which would have made Marchiafava Bignami syndrome unlikely. Although predominantly of white matter, the appearances are not those of a leukodystrophy or CADASIL or MS / ADEM. HIV negative and non immunosuppressed makes PML unlikely (and again I am not sure it involves the cc to this extent). There was a vague history of hyponatremia does raise the possibility of extrapontine demyelination, however I am not aware of it involving the body of the CC (rather the splenium).
Other possibilities include a leukoclastic vasculitis / encephalitis illness e.g. SLE, systemic sclerosis etc..