Case contributed by A.Prof Frank Gaillard

Patient Data

Age: 33 years
Gender: Male

Large hyperdense posterior fossa mass, with significant positive mass effect on the brain stem and fourth ventricle resulting in lateral and third ventricular dilatation with periventricular low density, in keeping with transependymal spread of CSF.


Case Discussion

33 year old man

Final Diagnosis: 

Posterior fossa tumour, resection: Medulloblastoma.

Microscopic Description: 

Several tissue fragments that are diffusely infiltrated by a densely cellular neoplasm consisting of closely packed tumour cells with increased nuclear/cytoplasmic ratio, oval, round or carrot-shaped hyperchromatic nuclei and scant cytoplasm. The tumour cells form diffuse sheets with no pattern differentiation. There are numerous apoptotic nuclei. In some areas the tumour cells tend to display clear cytoplasm around central round nuclei. The mitotic activity varies, being frequent in some parts of the tumour and less conspicuous in others. Most tumour cells are strongly immunoreactive for synaptophysin and there are frequent areas of intense immunoreactivity for neuron-specific enolase (NSE). Staining for neurofilament protein is negative. A few GFAP-positive reactive astrocytes are seen scattered in the tumour. The MIB-1 stain shows many cells in the mitotic cycle.

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Case information

rID: 5300
Published: 1st Jan 2009
Last edited: 22nd Sep 2015
Inclusion in quiz mode: Included

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