Medulloblastoma

Case contributed by Dr Abdallah Khateeb

Presentation

Young male patient presenting with general weakness and vertigo.

Patient Data

Age: 22
Gender: Male
CT

Brain CT

The CT images show a slightly hyperdense large left posterior fossa mass that causes distortion of the fourth ventricle and CSF cisterns and obstructive hydrocephalus. Also there are small areas on necrosis. No calcifications seen. The mass enhances homogenously following contrast administration.

MRI

Enhanced brain MRI

MRI shows that the mass is hypointense on T1 images, isointense on T2/FLAIR, with adjacent vasogenic edema, containing small areas of cystic component. Restricted diffusion and enhancement following Gadolinum are evident. 

Case Discussion

Imaging of the whole neuraxis was performed and showed no drop metastasis.

Surgical resection was performed.

HISTOPATHOLOGY REPORT

MACROSCOPIC DESCRIPTION

- Examined sections of tumor revealed a small round blue cell tumor, composed of sheets and nodules of undifferentiated cells with minimal cytoplasm, hyperchromatic and anaplastic nuclei, often elongated and carrot-shaped with occasional Homer-Wright rosettes. Frequent mitotic figures, with delicate desmoplastic reaction are also seen. The tumor cells are positive for synaptophysin and negative for GFAP, Chromogranin and NSE.

DIAGNOSIS
- Medulloblastoma grade IV.

PlayAdd to Share

Case information

rID: 43295
Case created: 3rd Mar 2016
Last edited: 7th Nov 2016
Inclusion in quiz mode: Included

Updating… Please wait.
Loadinganimation

Alert accept

Error Unable to process the form. Check for errors and try again.

Alert accept Thank you for updating your details.