Medulloblastoma - adult

Case contributed by Assoc Prof Frank Gaillard

Patient Data

Age: 35 years
Gender: Female
CT

CT brain

There is a mixed solid and cystic mass surrounded by peritumoural edema within the left cerebellar hemisphere.

The solid component appears slightly hyperdense. Following administration of contrast, vivid enhancement of the solid component is present.

MRI

MRI brain

MRI demonstrates a mass within the left cerebellar hemisphere. It is composed of mixed solid and cystic components with peritumoural edema.

The solid component demonstrates restricted diffusion on DWI and avid enhancement of the solid component post contrast administration.

Case Discussion

The differential is of a hemangioblastoma, high grade glioma, a metastasis or an adult medulloblastoma. The hypderdensity, exccentric location, and restricted diffusion are all consistent with the latter, confirmed at pathology. 

Histology

Microscopic Description:

Sections show a highly cellular tumor mass composed of cells with hyperchromatic oval nuclei and little visible cytoplasm. The nuclei have coarsely clumped chromatin and inconspicuous nucleoli. Mitotic activity and individual cell necrosis and apoptosis are frequent. In some areas, the nuclei show a tendency to mold to one another. The cells are arranged in solid disorganized sheets and in small lobules and columns separated by collagenous septa. Multiple small cystic spaces are present but there is no geographic necrosis. One small fragment of recognizable cerebellar cortex is present and shows diffuse infiltration by neoplastic cells. Immunohistochemistry shows diffuse cytoplasmic reactivity for NSE and synaptophysin and occasional cells are positive for GFAP and S-100. The tumor is negative for cytokeratin, LCA, HMB-45 and Mel A.

Final diagnosis: Medulloblastoma

 

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Case information

rID: 5328
Published: 3rd Jan 2009
Last edited: 8th May 2021
Inclusion in quiz mode: Included