Ménétrier disease

Case contributed by Rania Adel Anan
Diagnosis certain


Chronic upper abdominal pain.

Patient Data

Age: 35 years
Gender: Male

Thickened hyperenhancing gastric rugal folds (mainly at the body) projecting into the gastric lumen (resembling brain convolutions) with normal gastric wall thickness in between.

Diffuse hypertrophy of the pyloric muscle also noted.

Case Discussion

Pathology confirmed the diagnosis of Ménétrier disease.

This patient underwent gastrectomy.

Ménétrier disease is a rare disease with an incidence of <1 per 200,000. Bimodal in distribution,  usually occurs in children younger than 10 years and the second peak occurs in adulthood between 30 and 60 years of age, with male predilection in both the juvenile and adult forms.

The main imaging differential considerations for diffuse rugal thickening include:


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