Meningioma with rhabdoid component

Case contributed by Dr Bruno Di Muzio

Presentation

Not available.

Patient Data

Age: 50 years
Gender: Female

MRI brain showing an enhancing left cerebellopontine angle tumour with extension into the left internal auditory promoting its enlargement. The mass seems to displace both the VII and VIII cranial nerves inferiorly. The remainder exam remains unremarkable. 

Pathology

MICROSCOPIC DESCRIPTION: Paraffin sections show fragments of a moderately hypercellular meningioma. This has a well developed syncytial architecture. The majority of tumour cells have uniform nuclear features. However, there are scattered foci in which tumour cells have rhabdoid features with eccentric nuclei and a large amount of granular eosinophilic cytoplasm. These features are seen in <50% of tumour cells. No anaplastic features in the form of mitoses or necrosis are seen. There is no evidence of brain invasion.

DIAGNOSIS: "Left cerebello-pontine angle tumour": Meningioma with focal rhabdoid features COMMENT: Foci of tumour cells with rhabdoid features indicate the potential for aggressive behaviour. However, the criterion of at least 50% of tumour cells showing rhabdoid features, for a diagnosis of a WHO Grade III tumour, is not met. 

Case Discussion

This cases illustrates a typical radiologic appearance of enhancing CPA mass, being the most likely differential diagnosis made between a schwannoma and a meningioma

The histopathologic studied revealed a meningioma with the presence of foci of tumour cells with rhabdoid features indicating the potential for aggressive behaviour. However, the criterion of at least 50% of tumour cells showing rhabdoid features, for a diagnosis of a WHO Grade III tumour, is not met.

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Case information

rID: 36936
Case created: 19th May 2015
Last edited: 15th Feb 2016
Tag: rmh
Inclusion in quiz mode: Included

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