Mesial temporal sclerosis and pineal cyst

Case contributed by Dr Trent Orton



Patient Data

Age: 20 years
Gender: Female

The left hippocampus is small and of high T2 signal. Incidental pineal cyst noted. 

Case Discussion

The patient went on to have an amygdalohippocampectomy. 


Microscopic Description:

Sections of the mesial block confirm a mild to moderate loss of neurons within CA1 of hippocampus. Although this is sufficient to permit a diagnosis of mesial temporal sclerosis, the changes are relatively mild. There are no other major features of cortical dysplasia or cerebral dysgenesis in the mesial structures. There is no evidence of neoplasia, vascular malformation, or a previous cranial cerebral trauma. The sections of the remainder of the lateral block show focal cerebral micro-dysgenesis with a localized aggregate of neurocytic-type cells. There is no significant cortical dysplasia in the material examined. There is retraction of perivascular white matter.

Final diagnosis: 

Mesial temporal sclerosis

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Case information

rID: 4926
Published: 4th Nov 2008
Last edited: 23rd Sep 2015
Inclusion in quiz mode: Included

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