Metastatic neuroblastoma

Case contributed by Dr Sepehr Haghighi


Known case of neuroblastoma referred for vomiting

Patient Data

Age: 10 months
Gender: Female

There are multiple lytic metastases involving left greater sphenoid wing, left frontal bone and left inferomedial wall of orbital bone with spiculated periostitis ( hair-on-end). The mass at left frontal bone has extradural component.

These masses are related to multiple metastatic neuroblastoma.

Case Discussion

Craniocerebral neuroblastoma metastases usually involve the calvaria, orbits, skull base and the dura.

Radiographic features:


  • spiculated periorbital bone mass, typically involving the roof or lateral wall/sphenoid wings
  • "hair on end" spiculated periostitis of orbits and skull usually associated with bone destruction
  • sutural separation: non-uniform sutural separation with indistinct sutures margins
  • cranial metastasis nearly always extradural (may mimic epidural or subdural hematoma)
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Case information

rID: 65941
Published: 2nd Feb 2019
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included
Institution: Children's medical center

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