Metastatic thigh liposarcoma

Case contributed by Dr Ian Bickle


Thigh mass for 2 years. Now getting much bigger. No weight loss. Lipoma or sarcoma?

Patient Data

Age: 30 years
Gender: Female

MRI thigh (with contrast)

Well-delineated 20.4 x 14.7 x 11 cm lobulated mass in the thigh abutting, but not infiltrating the thigh musculature.

The mass contains multiple thin septae and fatty elements. Mild enhancement of the solid components.

No local lymphadenopathy.

Multiple high T2 foci within the femur, the largest 6cm at the proximal metaphysis.

Comment: appearances highly suggestive of a liposarcoma

The signal changes in the femur suggest osseous involvement.


1. MRI full femur length to include knee and hips joints



Patient recalled to ensure full upper leg covered

Distal femur covered. Whole femur covered in conjunction with the original imaging.

Huge thigh mass as previously reported in keeping with a liposarcoma.

Multiple infiltrative marrow lesions in the whole length of the femur. The largest 6.1 cm in the distal diaphysis and the most distal lesion of all in the metaphysis measuring 1.4 cm.

Comment: liposarcoma with osseous femoral skip lesions. 



4 mm subpleural ground glass nodules in the lateral segment of the left lower lobe.

1.5 cm lesion in the upper outer aspect of the right breast and lower inner aspect of the right breast.

No mediastinal nodes.


Circumferential rind of paravertebral soft tissue measuring 2.5 cm in depth at T12-L1. The soft tissue extends into the epidural/dural spaces at these levels.

Minor scalloping of the posterior aspects of T12 and T1 likely related to the aforementioned soft tissue extension.

Three metastases the largest measuring 2.6 and 1.6 cm in segment 5 of the liver.

6.2 cm mass in the right side of the pelvis compressing the lateral bladder wall. 3.5 cm peritoneal metastases posterolateral the left kidney.


1. T12-L1 paraspinal tissue with soft tissue extension - advise MRI whole spine to assess

2. liver and pelvic lesions - consistent with metastases in the context of the thigh mass (liposarcoma)

3. right breast lesions - dedicated imaging merited


MRI performed after CT findings

Counting from C2, the last unfused vertebra is taken as L5. Spinal cord ends normal at L1 level.

Moderately enhancing masses are involving almost the entire spine, hypointense on T1 and intermediate signal on T2 images, though preserved vertebral body and disc heights.

There is associated paraspinal extension of the lobulated masses with anterior epidural extension at T11–L2 levels, resulting in significant spinal canal stenosis and compression of the cord and nerve roots in the cauda equina.

Anterior epidural extension of the mass is also noted at C7–T2 levels causing mild to moderate spinal canal stenosis and abutting the cord.

6.7 cm lobulated soft tissue mass in the right side of pelvic cavity, compressing right lateral wall of the bladder. 3.5 cm left retroperitoneal nodule.

Case Discussion

The breast and thigh lesion were both biopsied.

THIGH: A malignant tumor composed of lipoblast in a myxoid stroma.

Conclusion: mxyoid liposarcoma

BREAST: round to short spindle cells in a myxoid background. Vimentin positive. S100, CD68, CD34 and desmin negative.

Conclusion: myxoid liposarcoma

Quite a remarkable case of diffuse metastatic disease from a thigh liposarcoma including the rare occurance of breast metastases.

The thigh mass was present for several years prior and presumably metamorphasized into a malignancy.

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Case information

rID: 59737
Published: 7th May 2018
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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