Microcephaly with simplified gyral pattern

CT features most consistent with microcephaly with simplified gyral pattern, group I.A according to the Classification system for malformations of cortical development.

Microcephaly can be divided into:

• congenital (primary or true) microcephaly: the brain never forms normally. the cause is genetic and usually associated with simplified gyral pattern with normal cortex thickness

• acquired (or secondary) microcephaly. usually associated with cerebral cortical malformations (such as lissencephaly or holoprosencephaly) and result from brain injury (such as hypoxic-ischaemic insult, cerebral infection, or metabolic disease)

Case courtesy Dr M. Slougui, MD, CHU Constantine, Algeria