Mineralizing microangiopathy

Case contributed by Dr Miguel Angel Pedraza


Received radiotherapy (17 sessions) post-surgical resection of a posterior fossa medulloblastoma.

Patient Data

Age: 8 years
Gender: Male

Bilateral dystrophic calcifications at the corticomedullary junction in the posterior temporal and occipital lobes, the lentifrom nuclei and the lateral aspect of both thalamus.

Lacunar infart in the deep right parietal white matter.

Ventricular shunt at the frontal horn.

Occipital craniectomy.

Case Discussion

Mineralizing microangiopathy is one of the complications of cranial radiotherapy, consist of late sequelae with typical dystrophic calcifications at the corticomedullary junction, lentiform nuclei and the dentate nucleus. In this pediatric case with a previous resection of medulloblastoma, those are more evident at the posterior temporal and occipital lobes.

Differential diagnosis includes Fahr's Syndrome (e.g. hyperparathyroidism, hypoparathyroidism, pseudohypoparathyroidism) and cortical laminar necrosis.

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Case information

rID: 82878
Published: 9th Oct 2020
Last edited: 26th Nov 2020
Inclusion in quiz mode: Included

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