Mixed epithelial and stromal tumour (MEST)

Case contributed by Dr Andrew Ryan


Complex renal cyst on imaging.

Patient Data

Age: 50
Gender: Male

Partial nephrectomy specimen with overlying perinephric fat (transverse section)

The partial nephrectomy specimen confirmed a multilocular cystic lesion, 15 x 12 x 12 mm

The sections show a multilocular cystic lesion, arising from the renal cortex. The lesion bulges into but shows a circumscribed interface with the perinephric fat.

Case Discussion

This is an example of mixed epithelial and stromal tumour (MEST), a benign mixed mesenchymal and epithelial neoplasms of the kidney. The tumour is composed of dilated tubules and cysts lined by a simple layer of epithelium, often with surface 'hobnail' outline, surrounded by variably fibrous to spindled to muscular stroma, often described as 'ovarian-like stroma'.

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Case information

rID: 36856
Case created: 13th May 2015
Last edited: 27th Sep 2015
System: Urogenital
Inclusion in quiz mode: Excluded