Mixed epithelial and stromal tumour (MEST)

Case contributed by Dr Andrew Ryan

Presentation

Complex renal cyst on imaging.

Patient Data

Age: 50
Gender: Male
Pathology

Partial nephrectomy specimen with overlying perinephric fat (transverse section)

The partial nephrectomy specimen confirmed a multilocular cystic lesion, 15 x 12 x 12 mm

The sections show a multilocular cystic lesion, arising from the renal cortex. The lesion bulges into but shows a circumscribed interface with the perinephric fat.

The lesions is multilocular with intervening areas of cellular stroma.

Variably sized epithelial lined tubules and cysts surrounded by fibromuscular stroma. 

Columnar surface epithelium overlying cellular fibromuscular stroma.

The stroma characteristically shows positive staining for ER

Case Discussion

This is an example of mixed epithelial and stromal tumour (MEST), a benign mixed mesenchymal and epithelial neoplasms of the kidney. The tumour is composed of dilated tubules and cysts lined by a simple layer of epithelium, often with surface 'hobnail' outline, surrounded by variably fibrous to spindled to muscular stroma, often described as 'ovarian-like stroma'.

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Case information

rID: 36856
Published: 13th May 2015
Last edited: 10th Apr 2018
System: Urogenital
Inclusion in quiz mode: Excluded

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