CLINICAL NOTES: no/ evidence of metastatic disease ?mucocele of appendix healthy appendiceal base good margin macroscopically
MACROSCOPIC DESCRIPTION: An appendix 75mm long ranging in diameter between 3mm at the neck and up to 23mm in the mid portion. A small amount of mesoappendix is attached, up to 20mm wide, 7mm thick. The serosa is pale tan and smooth with no wall defect. The middle segment of the appendix appears dilated over a length of 25mm. The resection margin is inked green. On sectioning the entire lumen is filled with and distended by white mucinous material. The mucosa is diffusely flattened and appears focally thickened and tan.
BLOCK DESIGNATION: A - LS from the resection margin. B - LS from the tip of the appendix and area of thickened tan mucosa. C&D - TS from the distended segment with intraluminal material. P4. (GS)
MICROSCOPIC DESCRIPTION: Sections of appendix show a low grade appendiceal mucinous neoplasm composed of a focally undulating and focally eroded single layer of mucin producing columnar cells devoid of atypia. At the base of the ulcer there is extensive dystrophic calcification and a patchy lymphocytic infiltrate. The entire appendiceal mucosa is replaced and the epithelium of this neoplasm abuts the underlying muscularis propria. Large copious amounts of mucin is found within the lumen. There is no evidence of invasion into the underlying stroma. The excision appears complete.
DIAGNOSIS: Appendix: Low grade appendiceal mucinous neoplasm completely excised. No high grade area or evidence of invasive malignancy. Further sections show no further pathology.