Multicenteric histiocytosis

Case contributed by Dr Aneta Kecler-Pietrzyk


Weight loss and anemia. Joint deformity of both hands with multiple overlying skin nodules.

Patient Data

Age: 75 years
Gender: Female

Bilateral extensive erosive arthropathy involving all fingers intercarpal joints. Further degenerative changes are noted involving wrist and base of thumb.

Prior plate and screw fixation of the right distal radius.

Of note, these changes were not seen on hand x-ray two years prior (not shown). 

Case Discussion

Extensive erosive bilateral small joint arthropathy has a wide differential including: 

  • rheumatoid arthritis
  • psoriatic arthropathy
  • erosive osteoarthritis

Please see full list please see: erosive arthritis (differential).

In this case, skin nodules overlying hand joints were biopsied and the patient was found to have multicentric histiocytosis.


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Case information

rID: 54422
Case created: 9th Jul 2017
Last edited: 12th Jul 2017
Inclusion in quiz mode: Included

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