Multinodular and vacuolating neuronal tumour

Case contributed by Dr Y. Amy Chen

Presentation

Headache and seizure-like episodes

Patient Data

Age: 55 years
Gender: Female

Cluster of "bubbly" T2 hyperintense lesions located in the subcortical white matter of the right temporal lobe, without associated restricted diffusion or enhancement.

The patient went on to have surgery confirming the diagnosis. H&E stain shows neurons with vacuoles in their cytoplasm, as well as free-floating vacuoles throughout the specimen.

Case Discussion

Multinodular and vacuolating neuronal tumour (MVNT) is an indolent tumour. MRI shows discrete, well-demarcated, "bubbly" T2/FLAIR hyperintense lesions found within the subcortical white matter. Histology shows vacuolar changes in neurons. The lesions may be identified incidentally, or during workup of patients with chronic seizures.

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Case information

rID: 51347
Case created: 12th Feb 2017
Last edited: 13th Feb 2017
Inclusion in quiz mode: Included

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