Presentation
Headache and seizure-like episodes
Patient Data
Age: 55 years
Gender: Female
From the case:
Multinodular and vacuolating neuronal tumor
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Cluster of "bubbly" T2 hyperintense lesions located in the subcortical white matter of the right temporal lobe, without associated restricted diffusion or enhancement.
From the case:
Multinodular and vacuolating neuronal tumor
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The patient went on to have surgery confirming the diagnosis. H&E stain shows neurons with vacuoles in their cytoplasm, as well as free-floating vacuoles throughout the specimen.
Case Discussion
Multinodular and vacuolating neuronal tumor (MVNT) is an indolent tumor. MRI shows discrete, well-demarcated, "bubbly" T2/FLAIR hyperintense lesions found within the subcortical white matter. Histology shows vacuolar changes in neurons. The lesions may be identified incidentally, or during workup of patients with chronic seizures.