Multinodular and vacuolating neuronal tumor

Case contributed by Dr Y. Amy Chen


Headache and seizure-like episodes

Patient Data

Age: 55 years
Gender: Female

Cluster of "bubbly" T2 hyperintense lesions located in the subcortical white matter of the right temporal lobe, without associated restricted diffusion or enhancement.

The patient went on to have surgery confirming the diagnosis. H&E stain shows neurons with vacuoles in their cytoplasm, as well as free-floating vacuoles throughout the specimen.

Case Discussion

Multinodular and vacuolating neuronal tumor (MVNT) is an indolent tumor. MRI shows discrete, well-demarcated, "bubbly" T2/FLAIR hyperintense lesions found within the subcortical white matter. Histology shows vacuolar changes in neurons. The lesions may be identified incidentally, or during workup of patients with chronic seizures.

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