Multiple cerebral cavernous malformations

Case contributed by James Harvey
Diagnosis certain

Presentation

Seizures since infancy. Presented to ED following a prolonged seizure.

Patient Data

Age: 20 years
Gender: Female

Several dense calcified lesions are seen. A well-circumscribed lesion involves the cingulate gyrus and body of the corpus callosum.

There is no enhancement on the post-contrast study.

MRI brain

mri

Multiple areas of SWI blooming artefact representing cavernous malformations are seen within the supra and infratentorial brain parenchyma. The largest one in the right frontal region is heterogeneous with predominant hyperintense foci involving the grey and white matter.  Blooming artefacts noted within in keeping with blood products.

Numerous other cavernous malformations are seen.

Case Discussion

Cavernous malformations are usually isolated. Where multiple cavernous malformations are present, familial multiple cavernous malformation syndrome must be considered. This condition typically presents with seizures. The inheritance pattern is autosomal dominant, with variable penetrance.

This patient had undergone previous surgical evacuation of hemorrhage within the right frontal lobe.

How to use cases

You can use Radiopaedia cases in a variety of ways to help you learn and teach.

Creating your own cases is easy.