Multiple myeloma

Case contributed by Dr Bruno Di Muzio


Generalised malaise, neck and shoulder pain. Found to be hypercalcaemic.

Patient Data

Age: 55-year-old
Gender: Male

Throughout the imaged skeleton there are extensive lytic lesions with associated soft tissue components.

There are lesions in the scapulae, throughout the thoracic and lumbar spine, manubrium, multiple ribs bilaterally, throughout the bony pelvis and also in the left femoral neck.​

Pathological fractures of the T1 left lamina and L3 vertebral body.

Patient underwent biopsy that revealed: 

MICROSCOPIC DESCRIPTION: The sections show fragments of mature lamella bone admixed with mature adipose and some devitalised bone fragments. Scattered throughout the specimen are variably sized sheets of plasmacytoid cells with uniform round to slightly oval nuclei with hypochromatic vaguely clock face chromatin, eccentrically placed nucleus and a small amount of eosinophilic cytoplasm. Mitoses are noted. Normal haematopoietic tissue is also seen. The appearances are in keeping with plasma cell myeloma.

DIAGNOSIS: Left femur reamings: Features consistent with plasma cell myeloma (multiple myeloma).

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Case information

rID: 45624
Published: 7th Jun 2016
Last edited: 12th Jun 2016
Tag: rmh
Inclusion in quiz mode: Included

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