Myelodysplastic syndrome with osteomyelosclerosis
Patient was recently short of breath and imaging was performed to exclude PE. Patient has also a known myelodysplastic syndrome.
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CT in the bone window demonstrates dense, somewhat inhomogeneous bone structure throughout the skeleton.
The patient has a known MDS which may involve myelofibrosis of the bone marrow and osteomyelosclerosis in the long term, as presented in this case. The osteosclerosis is diffuse but inhomogeneous throughout the skeleton. A reduction of active hematopoietic marrow leads to anemia and possible extramedullary hematopoiesis as well as splenomegaly. MDS may convert into leucemia later in life. Also, pulmonary hypertension is seen in patients with myelofibrosis, possibly the cause for the patients pulmonary symptoms.
- Guermazi A, de Kerviler E, Cazals-Hatem D et-al. Imaging findings in patients with myelofibrosis. Eur Radiol. 1999;9 (7): 1366-75. doi:10.1007/s003300050850 - Pubmed citation
- Diamond T, Smith A, Schnier R et-al. Syndrome of myelofibrosis and osteosclerosis: a series of case reports and review of the literature. Bone. 2002;30 (3): 498-501. Pubmed citation