Myelodysplastic syndrome with osteomyelosclerosis

Case contributed by Dr Björn Jobke


Patient was recently short of breath and imaging was performed to exclude PE. Patient has also a known myelodysplastic syndrome.

Patient Data

Age: 72
Gender: Female

CT in the bone window demonstrates dense, somewhat inhomogeneous bone structure throughout the skeleton.

Case Discussion

The patient has a known MDS which may involve myelofibrosis of the bone marrow and osteomyelosclerosis in the long term, as presented in this case. The osteosclerosis is diffuse but inhomogeneous throughout the skeleton. A reduction of active hematopoietic marrow leads to anemia and possible extramedullary hematopoiesis as well as splenomegaly.  MDS may convert into leucemia later in life. Also, pulmonary hypertension is seen in patients with myelofibrosis, possibly the cause for the patients pulmonary symptoms. 

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Case information

rID: 40566
Published: 27th Oct 2015
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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