Myositis ossificans progressiva

Case contributed by Dr Naim K

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Patient Data

Age: 30 years
Gender: Female

Pelvis, hips and both knees

X-ray

Extensive parosteal and periarticular soft tissue ossification are seen around both hips, more on the left side with ankylosis, and across both knee joints with ankylosis on the right side.

Similar changes are also seen around the left femoral shaft with deformity.

Findings are suggesting Myositis ossificans progressiva.

Case Discussion

Myositis ossificans, is the most common cause of heterotopic ossification usually within the large muscles. It exists in several forms, being benign in nature without malignant potential. Circumscripta subtype, is often post-traumatic. Fibrodysplasia ossificans progressiva is very rare subtype with heterotopic ossification starting between 2 and 5 years old and progressive in nature and fatal disease. Most cases arise from sporadic mutation and some other autosomal dominant inheritance pattern. ​

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