Presentation
Distended abdomen with palpable masses
Patient Data
Both kidneys are diffusely enlarged with lobulated contours. The normal renal cortical tissue is replaced by multiple soft tissue masses of low attenuation (nephrogenic rests), compressing the enhancing renal parenchyma centrally.
Case Discussion
Features consistent with nephroblastomatosis.
Nephroblastomatosis is a rare condition, considered as a precursor of nephroblastoma (Wilms tumor). It is characterized by the presence of multiple residual embryonal cells (nephrogenic rests). When isolated, the recommended treatment consists of chemotherapy followed by monitoring. In the presence of an associated nephroblastoma, treatment consists of preoperative chemotherapy followed by surgery, then postoperative chemotherapy and monitoring.
Additional contributor: Dr. R Bouguelaa, MD
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