Neuromyelitis optica (NMO)

Case contributed by A.Prof Frank Gaillard


Previous well with rapidly evolving lower upper motor neuron weakness and signs. Bladder dysfunction. Brain MRI normal.

Patient Data

Age: 41
Gender: Female

Involving the cervicaothoracic cord is a longitudinally extensive spinal cord lesion (LESCL) of abnormal T2 signal with cord swelling. The central cord is involved. No haemorrhage. 


Case Discussion

The patient went on to have extensive diagnostic work-up. 

  • Neuromyelitis Optica antibodies: POSITIVE
  • Rheumatoid Antibodies
    • Rheumatoid Factor <20 IU/mL (normal range: <20)
  • Antinuclear Antibodies
    • Antinuclear antibodies: POSITIVE
    • Speckled Titre: 40
    • Speck/Nuclr Titre: 640
  • Extractable Nuclear Antigens
    • Ext. Nuclear Ags Positive
    • Anti - Sm: Negative
    • Anti - RNP: Negative
    • Anti - Ro: POSITIVE
    • Anti - La: POSITIVE
    • Anti - Topo1: Negative
    • Anti - Jo1: Negative
  • Double Stranded DNA Antibodies
    • dsDNA 0.7  2.7 IU/mL (normal range: 0-4.0)
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Case information

rID: 32605
Case created: 5th Dec 2014
Last edited: 28th Oct 2015
Inclusion in quiz mode: Included

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