Non-ossifying fibroma

Case contributed by Mohammad Osama Hussein Yonso

Non-ossifying fibroma of the distal tibia: well-defined outline of the tumor with sharply defined sclerotic margins.

Case Discussion

Non-ossifying fibroma is one of the benign bone lesions, which are often asymptomatic unless accompanied by a pathologic fracture.

Differential diagnosis

  • fibrous dysplasia
  • hyperparathyroidism -Brown tumor
  • Brodie's and tuberculous abscesses
  • chondroma
  • benign osteoblastoma
  •  aneurysmal bone cyst
  • chondroblastoma
  • chondromyxoid fibroma.

Non-ossifying fibromas (NOF) are the most common of benign fibrous bone lesions 2 and is essentially a larger version ( >2-3 cm) of a fibrous cortical defect, both are encompassed by the term fibroxanthoma or metaphyseal cortical defect.

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