Oligoastrocytoma NOS

Case contributed by Dr Lawrence Chia Wei Oh


Past history of low grade glioma resection. Routine MRI follow-up

Patient Data

Age: 30 years
Gender: Female

This MRI brain demonstrates a non-enhancing lesion in the right frontal lobe. Given patient has previous history of low grade glioma, this highly suggests a recurrent tumour.

Case Discussion

The patient had a resection of the tumour and histology showed oligoastrocytoma (NOS).

NOTE: This case predates the 2016 WHO classification of CNS tumour revision. As no 1p19q co-deletion status is available a formal diagnosis cannot be reached and the NOS is therefore used (not otherwise specified) - which is recognised in the current classification for cases where molecular information is unavailable. It should also be noted, that under the new classification both an astrocytic and oligodendroglial component needs to be identified, each with its own molecular markers. True oligoastrocytomas are therefore going to be rare, and this case would most likely be classified as either an astrocytoma or an oligodendroglioma. Given extensive calcification, this is likely to be 1p19q co-deleted and most likely would be classified as an oligodendroglioma. Unfortunately, it is not possible to establish this in this historical case, as such one must fall back on the original histological diagnosis. 

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Case information

rID: 24652
Published: 2nd Sep 2013
Last edited: 16th Jul 2018
Inclusion in quiz mode: Included

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