Oligodendroglioma

Case contributed by Vanessa Döwich
Diagnosis almost certain

Presentation

This patient was asymptomatic and had no known previous pathologies. A hypodense lesion was observed in the left inferior frontal gyrus in a head CT performed in a trauma context, and investigation was continued with magnetic resonance imaging.

Patient Data

Age: 20 years
Gender: Male
mri

There was a corticosubcortical infiltrative and expansive lesion involving part of the pars triangularis and opercularis of the left inferior frontal gyrus, characterized especially by hypersignal on T2/FLAIR and hyposignal on T1, without enhancement or restricted diffusion. There was no signs of calcification or bleeding on SWI.

Case Discussion

This case demonstrates imaging findings of an oligodendroglioma proven by anatomopathological and immunohistochemical studies. The patient underwent surgical resection and the results are as follows:

  • immunohistochemical study: IDH-1: mild immunoreactivity; GFAP: no significant immunoreactivity; MAPc2: some cells with positive reactivity; Mib-1/Ki67: nuclear immunoreactivity in less than 3% of neoplastic cells; TP-53: no significant nuclear accumulation in the sample

  • anatomopathological/immunohistochemical conclusion: histological picture compatible with low-grade glial neoplasia (WHO grade II)

  • 1p19q co-deletion search: positive

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