Oligodendroglioma NOS

Case contributed by A.Prof Frank Gaillard
Modality: CT

Well circumscribed hypodense at most faintly enhancing left temporal lobe mass without calcification. 

Modality: MRI

Well circumscribed left temporal lobe tumour with minimal if any contrast enhancement demonstrates markedly high T2 signal and significant involvement of the overlying cortex. 

Case Discussion

The patient went on to have surgery and oligodendroglioma histology identified.

Note: This tumour predates the recent (2016) revision WHO classification of CNS tumours, and thus molecular markers (IDH mutation and 1p19q co-deletion) are not available. As such, this tumour would now be classified as oligodendroglioma NOS.

Note: Historically, oligodendrogliomas were considered well-circumscribed tumours, however when defined on the basis of IDH-mutation and 1p19q co-deletion, oligodendrogliomas appear to be a group of tumours with different morphology and recent studies suggest that in fact they have poorly defined borders 1. As such, it is at least possible that this case represents a diffuse astrocytoma according to current classification. 

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Case Information

rID: 5342
Case created: 5th Jan 2009
Last edited: 20th May 2017
Inclusion in quiz mode: Included

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