Oligodendroglioma NOS

Case contributed by A.Prof Frank Gaillard

Patient Data

Age: Adult
Modality: MRI

A relatively well circumscribed mass involves the temporal lobe and insular cortex, without convincing enhancement, and minimal restricted diffusion. 

Case Discussion

The patient went on to have a resection. 

Histology

Microscopic Description:

Sections show a moderately cellular glial neoplasm diffusely infiltrating the grey and white matter. Secondary structures are prominent in the subpial, perivascular and subependymal regions as well as perineuronal satellitosis. The vast majority of tumour cells have round to oval nuclei and perinuclear halos, some with mild degree of nuclear pleomorphism and hyperchromasia. Microgemistocytic forms are focally identified. Mitotic figures are occasionally seen. There are very minor foci of astrocytic differentiation showing more elongated nuclei and appreciable fibrillary processes. There is no evidence of vascular endothelial proliferation or tumor necrosis. GFAP immunostaining shows reactivity of the microgemistocytes and of a small number of cells in the few areas with focal astrocytic differentiation. MIB-1 immunostain shows low nuclear labelling.

The tumour is predominantly oligodendroglial, but a minimal astrocytic component is also noted. 

Final Diagnosis: Oligodendroglioma (WHO grade II).

Note: Unfortunately this case predates the recent (2016) revision WHO classification of CNS tumours, and thus molecular markers (IDH mutation and 1p19q co-deletion) are not available. As such, this tumour would now be classified as an oligodendroglioma NOS.

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Case Information

rID: 5397
Case created: 14th Jan 2009
Last edited: 20th May 2017
Inclusion in quiz mode: Included

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