Osteogenesis imperfecta

Case contributed by Dr Yair Glick


Premature neonate, one of twins born on 28th week of gestation. Osteogenesis imperfecta presumed from prenatal US scans.

Patient Data

Age: Neonate
Gender: Female

Endotracheal tube and umbilical arterial and venous catheters well placed. Patient on ventillator.
Multiple fractures incurred in utero at various stages of healing; many with malunion, angulation and bridging callus: multiple ribs bilaterally, left humerus, radii and ulnae, femora (segmental fractures in both), and fibulae.


AP and lateral views of head showing multiple wormian bones.

Case Discussion

Multiple fractures incurred in the womb in different stages of healing. Multiple wormian bones.
Diagnosis: osteogenesis imperfecta (OI), most probably type I.

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Case information

rID: 52436
Published: 9th Apr 2017
Last edited: 26th Apr 2017
Inclusion in quiz mode: Included

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