Cough and history of acute pulmonary edema.
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Lungs and pleural spaces clear with no features of APO.
Extensive sclerosis affecting all visible bones.
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The sandwich vertebral body sign is apparent. This can be mistaken for the rugger-jersey sign (associated with hyperparathyroidism) which appears less dense and less defined, or the picture frame vertebral body which also involves the lateral margins.
This patient had a prior confirmed diagnosis of autosomal dominant type 2 osteopetrosis and also suffers from associated pancytopenia and splenomegaly.
- Cleiren E, Bénichou O, Van Hul E, Gram J, Bollerslev J, Singer FR, Beaverson K, Aledo A, Whyte MP, Yoneyama T, deVernejoul MC. Albers-Schönberg disease (autosomal dominant osteopetrosis, type II) results from mutations in the ClCN7 chloride channel gene. Human molecular genetics. 2001 Dec 1;10(25):2861-7. https://academic.oup.com/hmg/article/10/25/2861/571328