Osteosarcoma of the distal femur

Case contributed by Lam Van Le
Diagnosis certain

Presentation

Swelling, pain, and limited range of motion in the left knee joint.

Patient Data

Age: 15 years
Gender: Male
x-ray

The findings on the radiograph include:

  • lesion is located at the distal femoral metaphysis, does not cross the physis, and extends in various directions

  • destruction and loss of distinction between bone marrow and cortical bone

  • wide transitional zone with indistinct borders

  • aggressive periosteal reaction of sunburst type and Codman’s triangle

  • invasion of adjacent soft tissue

  • osteoid matrix

  • no cortical expansion

MRI helps visualise the characteristics previously noted on the radiograph, showing tumour infiltration in the medullary canal and the metaphysis of the distal femur, not crossing the growth plate, with aggressive periosteal reaction (Codman's triangle), invasion, and formation of adjacent soft tissue mass, restricted diffusion, and strong contrast enhancement after injection.

(1) and (2) from left to right

pathology

Histopathology report (1):

  • sample location: distal femur tumour

  • staining method: Haematoxylin and Eosin

  • macroscopic: specimen size 1.0 x 0.2 cm

  • microscopic: tumour structure consists of bone fragments containing large, atypical nuclei with prominent nucleoli, along with haemorrhagic necrosis

  • conclusion: high-grade osteosarcoma

Histopathology report (2) :

  • sample location: soft tissue around distal femur tumour

  • staining method: Haematoxylin and Eosin

  • macroscopic: specimen core measuring 1.2 x 0.1 cm

  • microscopic: fibrous tissue infiltrated by numerous large, atypical nuclei, with areas of osteoid formation

  • conclusion: osteosarcoma with soft tissue invasion

Case Discussion

Imaging findings, pathology, and clinical symptoms are consistent with osteosarcoma.

This is the most common primary bone tumour in children.

Current treatment methods typically involve neoadjuvant chemotherapy, followed by surgical resection and adjuvant chemotherapy. Radiation therapy is less effective and rarely used.

Complications to note include pathological fractures and distant metastases (commonly seen in the lungs).

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