Presentation
Swelling, pain, and limited range of motion in the left knee joint.
Patient Data



The findings on the radiograph include:
lesion is located at the distal femoral metaphysis, does not cross the physis, and extends in various directions
destruction and loss of distinction between bone marrow and cortical bone
wide transitional zone with indistinct borders
aggressive periosteal reaction of sunburst type and Codman’s triangle
invasion of adjacent soft tissue
osteoid matrix
no cortical expansion



MRI helps visualise the characteristics previously noted on the radiograph, showing tumour infiltration in the medullary canal and the metaphysis of the distal femur, not crossing the growth plate, with aggressive periosteal reaction (Codman's triangle), invasion, and formation of adjacent soft tissue mass, restricted diffusion, and strong contrast enhancement after injection.



Histopathology report (1):
sample location: distal femur tumour
staining method: Haematoxylin and Eosin
macroscopic: specimen size 1.0 x 0.2 cm
microscopic: tumour structure consists of bone fragments containing large, atypical nuclei with prominent nucleoli, along with haemorrhagic necrosis
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conclusion: high-grade osteosarcoma
Histopathology report (2) :
sample location: soft tissue around distal femur tumour
staining method: Haematoxylin and Eosin
macroscopic: specimen core measuring 1.2 x 0.1 cm
microscopic: fibrous tissue infiltrated by numerous large, atypical nuclei, with areas of osteoid formation
conclusion: osteosarcoma with soft tissue invasion
Case Discussion
Imaging findings, pathology, and clinical symptoms are consistent with osteosarcoma.
This is the most common primary bone tumour in children.
Current treatment methods typically involve neoadjuvant chemotherapy, followed by surgical resection and adjuvant chemotherapy. Radiation therapy is less effective and rarely used.
Complications to note include pathological fractures and distant metastases (commonly seen in the lungs).