Ovarian dysgerminoma

Case contributed by Mahmoud Ibrahim Mekhaimar , 29 Dec 2019
Diagnosis certain
Changed by Mostafa Elfeky, 3 Jan 2020

Updates to Case Attributes

Age changed from 10 to 10 years.
Body was added:

Ovarian neoplasms can be divided into:

  • epithelial tumors: serous, mucinous, endometrioid, clear cell, Brenner and undifferentiated
  • germ cell tumors: teratoma (mature or immature), dysgerminoma, endodermal sinus tumor,  embryonal cell carcinoma and choriocarcinoma
  • sex cord-stromal tumors: granulosa-stromal cell tumors (granulosa cell tumor, fibrothecoma and sclerosing stromal tumor), Sertoli-stromal tumors (Sertoli-Leydig cell tumor) and steroid cell tumors
  • other tumors: metastatic tumors

Epithelial tumors are the most common and represent about 60% of all ovarian tumours. Dysgerminoma (type of germ cell tumors) is found mainly in young females. It is considered as the ovarian counterpart of seminoma of the testis. It is not associated with endocrine hormone secretion unless syncytiotrophoblastic giant cells are present which secrete HCG (5% of cases). Calcification can be present. Imaging findings are characterised by the presence of multi-lobulated solid masses with prominent fibrovascular septa.

  • +<p>Ovarian neoplasms can be divided into:</p><ul>
  • +<li>epithelial tumors: serous, mucinous, endometrioid, clear cell, Brenner and undifferentiated</li>
  • +<li>germ cell tumors: teratoma (mature or immature), dysgerminoma, endodermal sinus tumor,  embryonal cell carcinoma and choriocarcinoma</li>
  • +<li>sex cord-stromal tumors: granulosa-stromal cell tumors (granulosa cell tumor, fibrothecoma and sclerosing stromal tumor), Sertoli-stromal tumors (Sertoli-Leydig cell tumor) and steroid cell tumors</li>
  • +<li>other tumors: metastatic tumors</li>
  • +</ul><p>Epithelial tumors are the most common and represent about 60% of all ovarian tumours. Dysgerminoma (type of germ cell tumors) is found mainly in young females. It is considered as the ovarian counterpart of seminoma of the testis. It is not associated with endocrine hormone secretion unless syncytiotrophoblastic giant cells are present which secrete HCG (5% of cases). Calcification can be present. Imaging findings are characterised by the presence of multi-lobulated solid masses with prominent fibrovascular septa.</p>

References changed:

  • 1. Seung Eun Jung, Jae Mun Lee, Sung Eun Rha, Jae Young Byun, Jung Im Jung, Seong Tai Hahn. CT and MR Imaging of Ovarian Tumors with Emphasis on Differential Diagnosis1. (2002) RadioGraphics. 22 (6): 1305-25. <a href="https://doi.org/10.1148/rg.226025033">doi:10.1148/rg.226025033</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/12432104">Pubmed</a> <span class="ref_v4"></span>
  • Seung Eun Jung, Jae Mun Lee, Sung Eun Rha, Jae Young Byun, Jung Im Jung, Seong Tai Hahn. CT and MR Imaging of Ovarian Tumors with Emphasis on Differential Diagnosis1. (2002) RadioGraphics. 22 (6): 1305-25. <a href="https://doi.org/10.1148/rg.226025033">doi:10.1148/rg.226025033</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/12432104">Pubmed</a> <span class="ref_v4"></span>

Updates to Study Attributes

Findings was changed:
  • A large pelvi-abdominal multilocular complex cystic and solid heterogeneously enhancing soft tissue mass lesion measuring about 14.8 x 7.8 x 12.5 cm along its maximum axial and craniocaudal dimensions respectively.

  • it It is seen displacing the bowel loops upward and to the right.
  • faint Faint internal linear calcifications are noted.
  • moderate

    Moderate

    amount of pelvi-abdominal ascites. 

An enhanced MRI pelvis was requested.

Caption was added:
Abdomen

Updates to Study Attributes

Caption was added:
Pelvis
Findings was changed:
  • A large pelviabdominal multilocular complex soft and cystic mass lesion measuring about 14.8 x 7.8 x 12.5 cm along its maximum axial and CC dimensions respectively.

  • the The soft tissue component is seen eliciting low to intermediate T1, heterogeneous predominantly high T2 signal with restricted diffusion in the DWI. It showsheterogeneous enhancement in the post-contrast series.
  • innumerable Innumerable variable-sized cystic structures are seen eliciting low T1 and bright T2 signal. The largest of them measures about 7.3 x 5.4 cm in diameter.
  • the

    The

    uterus is average in size and of normal  myometrialmyometrial signal. The endometrium is seen thickened measuring about 18 mm in thickness, yet it appears hyperintense. Preserved junctional zone.
  • normal Normal MR appearance of the cervix and the vagina.
  • preserved

    Preserved

    follicular activity of the right ovary showing a dominant follicle measuring about 2.75 x 2 cm in
  • diameter.
  • inconspicuous Inconspicuous left ovary.
  • prominent

    Prominent

    bilateral external iliac and inguinal lymph nodes.
  • moderate

    Moderate

    amount of free pelviabdominal collection.
Images Changes:

Image MRI (T2) ( update )

Perspective was set to Axial.
Specifics was set to T2.

Updates to Study Attributes

Caption was removed:
pathology and diagnosis
Modality changed from Photo to Pathology.
Findings was removed:

Ovarian neoplasms can be divided into:

  1. epithelial tumors: serous, mucinous,  endometrioid, clear cell, brenner and  undifferentiated.
  2. germ cell tumors: teratoma (mature or immature), dysgerminoma, endodermal sinus tumor,  embryonal cell carcinoma and choriocarcinoma.
  3. sex cord–stromal tumors: granulosa-stromal cell tumors (granulosa cell tumor, fibrothecoma and sclerosing stromal tumor), sertoli-stromal tumors (sertoli-Leydig cell tumor) and steroid cell tumors.
  4. Other tumors: metastatic tumors
  • epithelial tumor is the most common one and represents about 60% of all ovarian tumours.
  • dysgerminoma (type of germ cell tumors) is found mainly in young females. it is considered as the ovarian counterpart of seminoma of the testis.
  • dysgerminoma is not associated with with endocrine hormone secretion unless syncytiotrophoblastic giant cells are present which secrete HCG (5% of cases).
  • calcification can be present.
  • imaging findings are characterized by the presence of multi-lobulated solid masses with prominent fibrovascular septa.

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