Pan-lobular emphysema due to alpha-1-antitrypsin deficiency

Case contributed by Jeremy Jones
Diagnosis certain


Severe breathlessness and recurrent infections

Patient Data

Age: 50 years
Gender: Male

Emphysema. Hyperexpansion with flattened diaphragms

Pan-lobular emphysema. Widespread severe emphysema with basal predominance.

Case Discussion

Pan-lobular emphysema with characteristic basal predominance. Severe destruction of the basal segments.  Widespread tracheal diverticulae that extend into the lower bronchial tree - associated with severe emphysema.

Subsequent investigation confirmed alpha-1-antitrypsin deficiency.

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