Papillary renal cell carcinoma
Left renal tumour.
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This is a papillary renal cell carcinoma removed by partial nephrectomy.
Macroscopic - Circumscribed, cortical-based, tan tumour with a cuff of renal parenchyma.
Microscopic (low power) - circumscribed lesion.
Microscopic (medium power) - well-defined interface of tumour and adjacent renal cortex (bottom left).
Microscopic (high power) - well-formed branching papillae with lining cells showing abundant eosinophilic cytoplasm and small uniform nuclei.
The features are consistent with a papillary renal cell carcinoma.
Papillary RCC is further subclassified on morphological and prognostic grounds into type I and type II; this is a good example of a type II papillary RCC with cores lined by larger lining cells with abundant eosinophilic cytoplasm, arranged in a 'pseudostratified' pattern (in areas the cells appear to be several layers thick, but are infact all still attached to the basement membrane).