Peripheral T cell lymphoma not otherwise specified (PTCL-NOS)
Citation, DOI and case data
Right lower abdomen-right groin swelling and fullness.
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Several hypodense hepatic foci, too small to characterize.
Angiomyolipoma in right kidney measuring 18 x 42 x 25 mm, protruding towards the liver.
The patient was referred to have a CT abdomen-pelvis after an ultrasound examination showed a cluster of enlarged lymph nodes in the right groin.
Following the CT, she underwent US-guided fine needle biopsy from those same inguinal lymph nodes.
4 cylinders of gray tissue 1.5-2 cm long.
Fragments of lymph node tissue showing diffuse non-atypical T cell proliferation and few scattered large cells that stained positive with CD30, MUM-1 and PAX5. CD15 stained some of them. No typical R-S cells were found. No eosinophils, plasma cells or histiocytes were seen in the background.
Following PCR test and repeat biopsy, the conclusion is that the tumor is compatible with a peripheral T cell lymphoma.
A 1.5 cm long cylinder of tissue and several tissue samples of 0.1-0.2 cm diameter.
Fragments of lymph node showing effacement of the architecture by a diffuse infiltration of small and intermediate-sized T cells positive for CD3, CD5 and CD4/
ALK-1 stain was negative.
CD30 and CD8 stained few scattered cells.
The proliferation index (Ki-67 markers) is about 40%.
Diagnosis: The findings are compatible with peripheral T-cell lymphoma, NOS.