Periventricular and corpus callosal glioblastoma

Case contributed by A.Prof Frank Gaillard

Irregular enhancing mass of the left splenium, left parietal lobe and left medial temporal lobe with surrounding vasogenic edema.

Case Discussion

Histological Diagnosis:

Brain, left parietal: Astrocytoma grade 4/4 (Glioblastoma) using the Daumas-Duport Grading System.

Microscopic Description:

Sections show pieces of a high-grade glioma displaying astrocytic characteristics predominantly. Areas of necrosis, including geographic areas of necrosis with nuclear pseudopalisading, are seen. Focal endothelial cell proliferation is observed. Some vessels display thrombotic occlusion of the lumen. Nuclear pleomorphism is increased. The tumour cells display, predominantly, astrocytic features. Mitotic figures are identified without difficulty.

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Case Information

rID: 5644
Case created: 2nd Mar 2009
Last edited: 10th Dec 2015
Inclusion in quiz mode: Included

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