Periventricular leukomalacia

Case contributed by Bouhouche Abdeldjalil
Diagnosis almost certain


Patient with known history of prematurity presenting with cerebral palsy.

Patient Data

Age: 17 years
Gender: Male
  • ventriculomegaly with irregular margins of the lateral ventricles (best seen on coronal images)

  • loss of periventricular white matter with increased T2/FLAIR signal and periventricular cysts

  • thinning of the corpus callosum

  • incidental note is made of left frontal, ethmoid and maxillary mucosal thickening

Case Discussion

History of preterm birth, clinical presentation and MR findings are consistent with periventricular leukomalacia.

Periventricular leukomalacia (a.k.a white matter injury of prematurity) is injury to the white matter surrounding the ventricles due to a variety of perinatal brain insults affecting preterm babies. It is common in very premature (less than 34 weeks gestational age), low birthweight babies (less than 1500 grams).

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