Physiologic age-related pituitary volume loss

Case contributed by Bálint Botz
Diagnosis not applicable

Presentation

Incidental finding.

Patient Data

Age: 20 years
Gender: Female

Normal study - not all sequences shown. Note the convex upper margin of the pituitary. 

14 years later

mri

Note flattening of the upper margin of the pituitary compared to the old study. The posterior pituitary "bright spot" is also far less bright than it was on the earlier study. 

Novel T2/FLAIR right frontal unidentified bright object (UBO) of unknown clinical significance. 

Again only selected sequences shown. 

Annotated image

Key images showing the involution of the pituitary. 

Case Discussion

Involution of the pituitary is to some extent physiologic, and its size and appearance should always be interpreted in the context of age, gender, and other factors such as pregnancy. When we compare the current status to a much older study the changes can be sometimes striking. 

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