Pituicytoma

Case contributed by Dr Natalie Yang

Presentation

None provided.

Patient Data

Age: 80 years
Gender: Female

MRI pituitary region

Modality: MRI

MRI of the brain and pituitary demonstrates a sizeable mass centered in the suprasellar and interpeduncular sellar, continuous with the infundibulum of the pituitary gland. It is isointense on T1 and iso- to perhaps slightly hyperintense on T2 weighted images. It enhances vividly. Normal pituitary tissue is seen in the bass of the fossa. 

The patient went on to have a biopsy. 

Histology

MACROSCOPIC DESCRIPTION: A fragment of cream / grey-tan tissue, approximately 4 x 3 x 2 mm.  (1.1) frozen section tissue.

MICROSCOPIC DESCRIPTION:  The tumour consists of nests and strands of cells within a collagenous fibrous stroma.  The tumour cells are generally  polygonal in shape but  in places they  become elongate.  In these areas  a fascicular   architecture  with focal  whorling  is present. Cytoplasm ranges from minimal to  moderate amounts of amphophilic material. The  nuclei  are  rounded or   somewhat  elongate,   with  finely  speckled chromatin.   Sometimes  small nucleoli  are  apparent.  There  is no tumour necrosis and mitotic  figures are  infrequent.   Immunohistochemical stains show no  staining  for  pituitary  hormones,   cytokeratins  or  epithelial membrane antigen. No convincing staining  for chromogranin or synaptophysin is found. There is,  however, strong  nuclear and  cytoplasmic staining for S100 with no staining for gp-100 or  melan-A. 

FINAL DIAGNOSIS: The morphologic and  immunohistochemical  features are  in keeping with the rare entity of pituicytoma 1.

Case Discussion

This case demonstrates appearances of a rare pituitary / infundibular tumour, a pituicytoma. This patient has been followed up for many years with little growth. 

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Case Information

rID: 2650
Case created: 7th May 2008
Last edited: 4th Jan 2016
Inclusion in quiz mode: Included

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