Pituitary adenoma - null cell
Adult male presenting with bitemporal hemianopia.
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The patient went on to resection which confirmed the diagnosis of null cell pituitary adenoma.
Paraffin sections show fragments of a moderately hypercellular adenoma. This is composed of cells with round and oval vesicular nuclei and a moderate amount of pale cytoplasm, arranged in diffuse sheets intersected by thin-walled capillaries. No mitotic figures or areas of necrosis are seen. Scattered acini of normal anterior pituitary cells are admixed with tumour.
No immunostaining for growth hormone, prolactin, ACTH, FSH, LH or TSH is seen in tumour cells. The features are of null cell adenoma.