Pituitary microadenoma-Cushing disease
Presented with Cushing disease, elevated cortisol & ACTH levels
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Right-sided 4-mm low signal intensity lesion abuts medial dural reflection of cavernous sinus. Left half of gland is normal. There's no abnormality of the stalk or remodeling of the sellar floor. There is no evidence of invasion of the cavernous sinuses.
Cushing syndrome is caused by excessive amounts of hydrocortisone and corticosterone released from the adrenal cortex.
- adrenal hyperplasia causes 70% of noniatrogenic Cushing syndrome, the hyperplasia is caused by 90% by "Pituitary microadenoma" causing hypersecretion of ACTH
- adrenal adenoma causes 20% of Cushing syndrome
- adrenal carcinoma cause 10%of Cushing syndrome
Pituitary microadenoma: <10mm in diamter 2
Dynamic contrast-enhanced thin-section T1 WI: it enhances but less rapidly than surrounding normal gland. 2
- nonneoplastic cyst
- incidental non functioning microadenoma
- 1. Brant WE, Helms CA. Fundamentals of Diagnostic Radiology. Lippincott Williams & Wilkins. (2007) ISBN:0781761352. Read it at Google Books - Find it at Amazon
- 2. Osborn AG, Salzman KL, Barkovich AJ. Diagnostic Imaging. Lippincott Williams & Wilkins. (2009) ISBN:1931884722. Read it at Google Books - Find it at Amazon