Pituitary microadenoma (GH)

Case contributed by RMH Neuropathology

Presentation

Acromegaly. Past history of oophorectomy for teratoma and BRCA2+ breast cancer with bilateral mastectomy.

Patient Data

Age: 61
Gender: Female
Modality: MRI

Hypoenhancing 5mm region on the left of the pituitary gland is typical of a microadenoma. 

Modality: Pathology

MICROSCOPIC DESCRIPTION:

The sections show a moderately cellular pituitary adenoma comprising trabeculae and nests, surrounded by vascularised stroma. The tumour cells have mildly enlarged round nuclei, conspicuous nucleoli and moderate amounts of granular eosinophilic cytoplasm. There are no atypical features. No normal anterior pituitary gland tissue is present. The tumour cells are diffusely and weakly positive for growth hormone. CAM5.2 shows only very occasional fibrous bodies (not shown). The Ki-67 index is about 1% (not shown). Immunostains for the other pituitary hormones are negative (not shown).

DIAGNOSIS: Pituitary tumour: Growth hormone secreting pituitary adenoma.

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Case Information

rID: 28128
Case created: 11th Mar 2014
Last edited: 7th Sep 2015
Inclusion in quiz mode: Included

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