Pituitary siderosis of iron overload
A known case of thalassemia with short stature and hypogonadism
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Midsagittal T1-weighted scan shows reduced height as well as abnormal low-signal intensity of the anterior pituitary lobe with preserved posterior sellar hot spot. Diffuse low signal of the examined (skull and upper cervical) bone marrow .
Increased iron concentration in the anterior pituitary gland can cause cause hypogonadotropic hypogonadism with growth hormone deficiency. The increased Iron accumulation in the Gonadotropin cell leads to its death secondary to iron toxicity that is probably the cause of the reduced pituitary gland height in thalassemia patients with hypogonadotropic hypogonadism.