Pituitary siderosis of iron overload

Case contributed by Dr Heba Abdelmonem


A known case of thalassemia with short stature and hypogonadism

Patient Data

Age: 25 years
Gender: Female

Midsagittal T1-weighted scan shows reduced height as well as abnormal low-signal intensity of the anterior pituitary lobe with preserved posterior pituitary bright spot. Diffuse low signal of the examined (skull and upper cervical) bone marrow.

Case Discussion

Increased iron concentration in the anterior pituitary gland can cause cause hypogonadotropic hypogonadism with growth hormone deficiency. The increased iron accumulation in the gonadotropin cell leads to its death secondary to iron toxicity that is probably the cause of the reduced pituitary gland height in thalassemia patients with hypogonadotropic hypogonadism.

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Case information

rID: 65358
Published: 6th Jan 2019
Last edited: 8th Apr 2020
Inclusion in quiz mode: Included
Institution: Zagazig University Hospital

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