Pleomorphic undifferentiated sarcoma
Left thigh swelling
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A large, well-defined, abnormal signal intensity mass lesion in the medial compartment of the left thigh, returning low signal intensity on T1, heterogeneous high signal intensity on T2/PD sequences with heterogeneous enhancement on post contrast image. No involvement of underlying bony structures.
This is a biopsy proven case of pleomorphic undifferentiated sarcoma.
Pleomorphic undifferentiated sarcoma, previously known as malignant fibrous histiocytosis (MFH) or undifferentiated spindle cell sarcoma (USCS), is a term that is used for the classification of sarcomas that cannot be assigned a cell of origin, whether by histological, immunohistochemical, ultrastructural, or molecular criteria 1.
Dr. Farhad Farzam has also contributed to this case.
- 1. Rubin BP, Nishijo K, Chen HI, Yi X, Schuetze DP, Pal R, Prajapati SI, Abraham J, Arenkiel BR, Chen QR, Davis S, McCleish AT, Capecchi MR, Michalek JE, Zarzabal LA, Khan J, Yu Z, Parham DM, Barr FG, Meltzer PS, Chen Y, Keller C. Evidence for an unanticipated relationship between undifferentiated pleomorphic sarcoma and embryonal rhabdomyosarcoma. (2011) Cancer cell. 19 (2): 177-91. doi:10.1016/j.ccr.2010.12.023 - Pubmed