Pleomorphic xanthoastrocytona - anaplastic

Case contributed by A.Prof Frank Gaillard
Modality: MRI

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Case Discussion

Pleomorphic xanthoastrocytoma with anaplastic features

Paraffin sections show a densely hypercellular glial tumour. Tumour cells are a mixture of gemistocytioc astrocytes and large cells with foamy, GFAP positive cytoplasm. There are also scattered large cells with markedly pleomorphic hyperchromatic nuclei. Frequent mitotic figures are noted (>10/10HPF) and there are occasional foci of vascular endothelial cell hyperplasia. Several perivascular cuffs of mononuclear inflammatory cells are also present. No necrosis is seen in any of the specimens submitted. The Ki-67/MIB-1 proliferationm index is approximately 8%. The features are of pleomorphic xanthoastrocytoma with anaplastic features.

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Case Information

rID: 6787
Case created: 18th Aug 2009
Last edited: 5th Dec 2015
Inclusion in quiz mode: Included

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