Soft tissue fillers are increasingly being used for rejuvenation of the face. Materials include mixed collagen and polymethylmethacrylate, calcium hydroxylapatite, bovine collagen, poly-L-lactic acid and hyaluronic acid. They are generally very safe but can be associated with granulomatous (foreign body) reaction especially hyaluronic acid. Some if injected too superficially can cause a skin reaction so injection may preferably be into the subcutaneous fat or even subperisoteal. If the injection is into muscle, then the filler can clump by way of muscular contraction even migrating way from the intended location overlying the anterior zygoma.