Post-transplant lymphoproliferative disorder: sinuses
Past history of leukaemia and bone marrow transplant 2 years earlier, presented with an enlarging ethmoidal mass.
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Right ethmoid, biopsy: Post-transplant lymphoproliferative disorder, diffuse large B-cell lymphoma type, EBV negative.
The biopsy shows area of diffuse infiltration by large pleomorphic lymphoid cells which show strong uniform expression of B cell marker CD20.
The majority of these tumors in the post-transplant setting are EBV positive.