Post-transplant lymphoproliferative disorder - sinuses
Past history of leukaemia and bone marrow transplant 2 years earlier, presented with an enlarging ethmoidal mass.
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The right ethmoidal air cells are destroyed by a soft tissue mass that extends into the orbit.
The patient went on to have a biopsy that confirmed the diagnosis of post-transplant lymphoproliferative disorder.
The biopsy shows diffuse infiltration by large pleomorphic lymphoid cells which show strong uniform expression of B cell marker CD20.
Post-transplant lymphoproliferative disorder, diffuse large B-cell lymphoma type, EBV negative.
Note: It should be noted that the majority of these tumours in the post-transplant setting are EBV positive.